We found that BHLHE41 and TIMELESS were upregulated in skin cutaneous melanoma patients, while BMAL1, BHLHE40, CRY2, HLF, NFIL3, NR1D1, PER1, PER2, PER3, RORA, RORC and TEF were downregulated. The gene discussed is BHLHE41; the disease is cutaneous melanoma.