We found that BHLHE41 and TIMELESS were upregulated in skin cutaneous melanoma patients, while BMAL1, BHLHE40, CRY2, HLF, NFIL3, NR1D1, PER1, PER2, PER3, RORA, RORC and TEF were downregulated. The gene discussed is TEF; the disease is cutaneous melanoma.