C57BL/6J mice were exposed alcohol for 3 weeks, their fear memory and recognition memory were impaired, while methylation of the BDNF promoter region in the hippocampal CA1 region was reduced, and the BDNF signaling pathway mediated by ERK, Akt and CREB was upregulated to counteract alcohol-induced cognitive deficits [116]. The gene discussed is BDNF; the disease is Cognitive impairment.