Moreover, integrin-linked kinase (ILK) is involved in integrin-mediated signaling, promotes the inhibition of phosphorylation of myosin phosphatase target subunit 1, and inactivates Merlin, a key upstream regulator of the Hippo pathway, which activates YAP/TAZ in a large–tumor suppressor kinase (LATS)-1/2-dependent manner [151]; meanwhile, the ILK-mediated deregulation of the Hippo-YAP/TAZ pathway plays an important role in formation of keloids and hypertrophic scars [152]. Here, YAP1 is linked to keloid.