Reduction of O-linked β-N-acetylglucosaminylation in AD patients has been implicated as a trigger of necroptosis [63].The activation of TNFR1-mediated necroptosis in hippocampal neurons of AD patients after death, and TNF-TNFR1 interaction, may be the main mechanism driving neurodegeneration in AD [64]. This evidence concerns the gene TNF and Alzheimer disease.