ESR1 and breast cancer: In the total population, including both pre- and post-menopausal women, a significant, dose-dependent inverse association between BC and dietary mushroom consumption was found in estrogen and progesterone receptor positive (ER+ PR+) patients (p < 0.001 for trend, multivariate analysis adjusted for confounding factors) but not in ER-/PR- patients (p > 0.05 for trend, multivariate analysis).