Induction of apoptosis associated with mitochondrial membrane potential decrease and decreased cdk4 and cyclin D1 resulting in cell cycle arrest; increased p21, p53, and Bax levels; inhibition of migration, autophagy induction [115,116,117,126]; reduction in tumor growth through suppression of cell proliferation and apoptosis promotion; inhibition of multiple pathways (PI3K-Akt-mTOR, ERK, p53) [118]. This evidence concerns the gene CDK4 and neoplasm.