Apoptosis induction through the release of CytC from mitochondria, alterations in genes involved in cell proliferation and invasion; upregulation of E-cadherin protein levels, promotion of cell adhesion, downregulation of cell motility and MMP2 and MMP9; decrease in β-catenin levels; modulation of Bax/Bcl2 ratio, affecting the pro-survival pathways related to PI3K/Akt and ERK [58,109]; immunomodulatory effects on macrophages, NK and T cells; decrease in metastasis; inhibition of carcinogenesis, angiogenesis, and cancer invasiveness; prolonged survival [58,109]. Here, BCL2 is linked to cancer.