On the other hand, miR-21-5p had significant correlations with markers related to kidney damage, and it has been previously described that this miRNA plays an important role in regulating pathways related to programmed cell death protein 4 (PDCD4) that inhibit the translation of initiation factor eIF4A, a helicase responsible for regulating the cell cycle and apoptosis. The gene discussed is PDCD4; the disease is Nephropathy.