Recent literature shows how PDRN improves the clinical signs of arthritis, decreases histological damage by restoring histological features, reduces the amount of many pro-inflammatory and apoptotic cytokines both in the blood and in the cartilage itself, and, on the other hand, increases the expression of anti-inflammatory cytokines such as interleukin-10 (IL-10) [20]. This evidence concerns the gene IL10 and Arthritis.