Since COVID-19 infection elicits the production of antibodies to all SARS-CoV-2 proteins, and Sputnik V vaccination produces antibodies only to the S-protein [42], as confirmed by the results of an ELISA, vaccinated patients who did not have COVID-19 were separated as a dependent group from patients vaccinated after contracting COVID-19. The gene discussed is PROS1; the disease is COVID-19.