TP53 and cancer: Moreover, we and others have demonstrated that p53 isoform expression contributes to deregulated p53 activities and may reveal novel avenues for cancer prognostication [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].