Over the years, multiple triggering factors of EMT have been identified, including (i) microenvironment signals (such as hypoxia and oxidative stress) [23], (ii) growth factors [epidermal growth factor (EGF), and fibroblast growth factor (FGF)] [24,25], and cytokines secreted by the tumor microenvironment [tumor necrosis factor-alpha (TNF-α), IL-8, IL-60] [26,27,28], (iii) immune responses (such as elevated expression of immune checkpoints, namely PD1, PD-L1, LAG3, and CTLA4) [29], and (iv) regulation of drug- and radio-resistance-related genes [23]. This evidence concerns the gene TNF and neoplasm.