HMGB1 and Hyperglycemia: An increased expression of HMGB1 and intercellular adhesion molecule 1 (ICAM-1) has been found as a result of ischemia-reperfusion damage, both with co-existing mild hyperglycemia (plasma glucose concentration = 150 mg/dL) and with transient severe hyperglycemia (plasma glucose concentration = 400 mg/dL).