TNF and lobular neoplasia: Recently, Su et al. [164] demonstrated that icariin isolated from Chinese medicine Horny Goat weed (Ying Yang Muo) could alleviate murine LN via suppressing the NK-kB activation, production of IL-1β, TNF-α and CCL2, macrophage infiltration, as well as the NLRP3 inflammasome triggering in autoimmune MRL/lpr mice.