NLRP3 and systemic lupus erythematosus: On the contrary, Tsao et al. [73] found that NLRP12, similar with NLRP3 in the same NLRP family encoding NACHT, LRR and PYD domains-containing proteins, was reduced in monocytes from lupus patients and mice, leading to a spontaneous activation of innate immune signaling and hyper-responsiveness to nuclear antigens.