UBE2O and Familial prostate cancer: This justify both genes UBE2T and UBE2O, and their respective protein expressions, being associated with several cancers and diseases, such as hepatocellular carcinoma [13], multiple myeloma (MM) [14], bladder [15], gastric cancer [16], multiple myeloma [11], breast and prostate cancer [6,17], and mixed-lineage leukemia [18].