In 2007, Sladek and coworkers identified four loci containing variants that confer T2D risk through a genome-wide association study, including a non-synonymous polymorphism in the ZnT8 gene (solute carrier family 30 member 8, SLC30A8), rs13266634 (C/T), which causes an R325W modification in the protein sequence [54]. This evidence concerns the gene SLC30A8 and type 2 diabetes mellitus.