For COL1A1, NR4A1 recruited Sp1, swi-independent-3 transcription regulator family member A (SIN3A), REST corepressor-1 (RCOR1 or CoREST, REST denoting RE1 Silencing Transcription Factor), histone deacetylase 1 (HDAC1) and Lysine(K)-specific demethylase 1A (KDM1A or LSD1) to an Sp1 binding site at -242 bp, repressing COL1A1 transcription in dermal fibroblasts from systemic sclerosis patients. The gene discussed is COL1A1; the disease is systemic sclerosis.