These include the Wnt-Planar Cell Polarity (PCP) pathway, an observation that was made in colorectal cancer cell lines where COL1A1 knock-down resulted in suppression of factors from this pathway (including the Ras-related C3 botulinum toxin substrate 1—Guanosine TriPhosphate (Rac1-GTP), phosphorylated JNK and Ras homolog family member A-GTP (RhoA-GTP). This evidence concerns the gene RHOA and colorectal cancer.