Along these lines, miR-23a and miR-28a were found to decrease COLα1 (I) protein levels in a CCl4 induced mouse model of liver fibrosis [93], and miR-1954 to reduce Col1a1 mRNA levels in an angiotensin II-induced mouse model of cardiac fibrosis [94]. This evidence concerns the gene COL1A1 and Hepatic fibrosis.