For the various types of cancer featured in this review, collagen I interacts with various receptors on cancer cells (including integrinβ, Endo180 or uPARAP, DDR, LAIR-1, CXCR2 and CXCR4), opening interesting perspectives for the development of new drugs targeting such interactions [21,41,83,108,109,110,120,121,123]. Here, MRC2 is linked to cancer.