COL1A1 and systemic sclerosis: Indirect evidence for the involvement of additional miRNAs in the regulation of Col1a1 mRNA in the context of fibrosis has also been accumulated; these include miR-21 and miR-141, as tested in fibroblasts from systemic sclerosis patients (miR-21 [90]) or myofibroblasts in the context of chronic liver disease (miR-141 [91]).