Nrf2 upregulates detoxifying enzymes, including NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and superoxide dismutase (SOD), and these have been shown to protect against NAFLD progression to varying degrees. The gene discussed is HMOX1; the disease is metabolic dysfunction-associated steatotic liver disease.