The neoadjuvant treatment of VAX014 in Fabp-CreXApcfl468, from 14 to 19 weeks, upregulated the expression of Il-6 (p = 0.04) in macroscopically normal colon tissues (Figure 4A) and TH1 and cytotoxic cell markers including Ifny (p = 0.05), Prf (p = 0.02), T-bet (p = 0.02), and the immunoregulatory cytokine, Il-10 (p = 0.05), in the large (≥4 mm2) adenomas of 26-week-old mice (Figure 4B). This evidence concerns the gene IL10 and adenoma.