CD40LG and colorectal cancer: However, it was interesting to see in preliminary studies in a surrogate CT26 colorectal cancer model that the expression of murine CD40-L and 4-1BBL was able to induce not only a clear anti-tumor immune-mediated response locally, but also a modest but statistically significant abscopal effect, especially when mice harboring established tumors were treated with preinfected CT26 cells.