(1)No effect of CARTPT on the association of IGF-1 serum level and BC risk.(2)No association between IGF-1 serum level and CARTPT.(3)GG genotype of CARTPT rs3846659 SNP increased the risk of BC in the group of patients with IGFBP-3 serum level in the highest tertile.(4)The presence of the C allele eliminated this effect. The gene discussed is IGF1; the disease is breast cancer.