Furthermore, MCC950, an NLRP3 inflammasome inhibitor, ameliorated podocyte injury, renal fibrosis, and renal dysfunction in db/db mice [25], and gasdermin D (GSDMD) knockdown using small interfering RNA (siRNA) in podocytes reversed hyperglycemia-induced inflammation and cell death [26]. Here, GSDMD is linked to renal fibrosis.