The expression of transcription factor Egr1 (early growth response protein 1) has been reported to be increased in the renal cortex of diabetic mice [30] and regulates NLRP3 inflammasome activation in the podocytes of a S-adenosylhomocysteine hydrolase (SAHH) inhibition-induced DN model [20]. Here, EGR1 is linked to liver dysplastic nodule.