Moreover, the activation of the PKC beta isoform via the ERK1/2 pathway augmented the expression of neuronal differentiation genes in neuroblastoma cells [192] and NPY upregulated genes containing the cAMP response element (including Y1R gene), via cAMP response element binding protein (CREB)/intracellular Ca++, in SK-N-BE2 neuroblastoma cells expressing Y1R/Y2R [193]. The gene discussed is MAPK3; the disease is neuroblastoma.