SLC5A1 and diabetes mellitus: Note that in diabetics, the effect of SGLT2 pharmacologic inhibition is partially offset by enhanced SGLT1 activation, while investigation in animals has provided conclusive evidence that SGLT1 can reabsorb ~30% of filtered glucose, explaining why SGLT2 inhibitors never produce the amount of glucosuria expected if SGLT2 were completely inhibited (preventing 80–90% reabsorption of the filtered glucose load) [57].