In addition, IL-7 signaling is necessary to induce the differentiation of Th1 cells rather than Th17 cells, and serum IL-7 levels correlate inversely with responsiveness to IFN-β therapy in Th1-mediated experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS) [14]. Here, IL7 is linked to myeloid sarcoma.