Based on the capacity of IFN-γ to negatively regulate both the activation and survival of AD-initiating effector cells (e.g., mast cells and basophils) [28,29], the IL-7 deficiency-mediated reduction in IFN-γ-producing T cells might be responsible for mast cell and basophil activation, which consequently could enhance AD development. Here, IFNG is linked to Alzheimer disease.