Inhibition of MAPK signaling in caerulein-induced pancreatitis in mice by treatment with a MEK inhibitor or by Mek1/2 knockdown blocked chronic pancreatitis development and reversed caerulein-induced damage, showing that MEK signaling is a driver of ADM required for initiation and maintenance of ADM and limiting organ regeneration [113]. Here, MAP2K7 is linked to chronic pancreatitis.