In addition, MT4-MMP-positive TAMs reduced, in a paracrine manner, E-cadherin expression in favor of mesenchymal N-cadherin, and vimentin in hepatocellular carcinoma cells, which is characteristic of the epithelial–mesenchymal transition (EMT) necessary for tumor metastasis [60]. The gene discussed is MT4; the disease is hepatocellular carcinoma.