Several cytokines and growth factors are abundantly produced in the TME of MM patients, including the ERBB1 ligands EGF, TGF-α, and AR, and cause activation of signal transduction pathways that have been implicated in the proliferation, prolonged survival, and dissemination of MM cells [50,51,52,53,54,55,56]. This evidence concerns the gene EGFR and Miyoshi myopathy.