Indeed, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD, genetic ablation, or pharmacological inhibition of sEH, attenuated dopaminergic neuron loss, reduced oxidative stress, and improved motor performance in the MPTP-treated mice [26,27]. This evidence concerns the gene EPHX2 and Parkinson disease.