PPIG and type 1 diabetes mellitus: Our findings demonstrated that administration of EPE to both S-NOD and Cyp-NOD mice decreased the incidence of T1D and reduced insulitis scores, with an increase in (green) immunofluorescence staining of Bcl-2 but a decrease in (red) immunofluorescence staining of Bax compared with both S-NOD and Cyp-NOD mice.