SCD and colorectal cancer: In U2OS and SW480 colorectal cancer cells, SCD1 depletion induced high-level induction of caspase-3 activity and PARP cleavage as well as unfolded protein response hallmarks such as Xbp1 mRNA splicing, phosphorylation of eIF2α and increased expression of the apoptosis-related protein C/EBP homologous protein [217].