Regarding other histopathological features of DCIS, the higher number of tumor-infiltrating DCs expressing DC-LAMP coexisted with the presence of ductal spread (pBH < 0.001), lobular cancerization (pBH = 0.009) and comedo necrosis (pBH = 0.02) (Table 2). This evidence concerns the gene LAMP3 and ductal breast carcinoma in situ.