It has been described that patients with severe COPD have an increase in non-classical monocytes, suggesting the development of a population of monocytes with a pre-M2 phenotype, more likely to differentiate into M2 macrophages in lung tissue after analysis of type markers M2, such as CD163 and CD206 [58,59,60]. This evidence concerns the gene MRC1 and chronic obstructive pulmonary disease.