Treatment with CDIM-8 or Cl-OCH3 leads to a decrease in the expression of PD-L1 in breast cancer cell lines (Hs578T, SUM159PT, MDA-MB-231, and 4T1), a lung cancer cell line (A549), a colon cancer cell line (SW480), and a kidney cancer cell line (786-0). This evidence concerns the gene CD274 and breast cancer.