One of the core marks of heart hypertrophy and heart failure is metabolic derangement, which affects different genes involved in metabolic hypertrophy response such as 5′-adenosine monophosphate-activated protein kinase (AMPK), NAD-dependent deacetylase sirtuin-1 (Sirt1), NAD-dependent deacetylase (NADD) or Liver kinase B1 (LKB1). The gene discussed is STK11; the disease is cardiac hypertrophy.