The first report on the importance of lncRNAs in cardiovascular disease was provided by Bischoff et al. (2017) describing that HypERlnc, a previously unknown lncRNA annotated as ENSG00000262454, represents a pivotal repressor of UPR by promoting the inhibition of ATF6, IRE1α and Bip transcriptional activation on pericytes exposed to hypoxia. Here, ATF6 is linked to cardiovascular disorder.