However, a recent report by Too et al. showed that populations from different geographic regions differ in ACPA fine specificities, and in a Malaysian population, the relationship between COL2 responses and HLA-DRB1 SE alleles was weaker compared to a group of Swedish RA patients included in epidemiological investigation of an RA (EIRA) study [99]. This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.