STX8 and rheumatoid arthritis: These findings could be related to joint COL2 supported by the well-known anti-CarB immunity, while evidence indicating the existence of anti-glycated collagen in RA development are scarce, despite the fact that glycation was proven in RA despite the absence of hyperglycemia [166] and increased levels of advanced glycation end products were detected in the serum, synovial fluid and urine of RA patients [167,168].