In the present work, we observed that pro-apoptotic proteins, Bad, Bax, and BID, are highly expressed in AGS and HT-29 cancer cells in response to 5-ISA- and 3,5-diISA-fortified lettuce vs. negative control (except BID after 3,5-diISA in AGS) (Figure 6A,B). The gene discussed is BAX; the disease is cancer.