To determine whether extracts from iodine-biofortified lettuce and synthetic forms of iodosalicylic acids inhibit cancer cell growth and proliferation through induction of apoptosis, the MuseTM Annexin V & Dead Cell Assay (Merck Millipore, Billerica, MA, USA) was performed (Figure 1 and representative plots in Supplementary Figure S1). This evidence concerns the gene ANXA5 and cancer.