TP53 and Familial prostate cancer: β-Lap has been shown to induce apoptosis in human colon cancer cells, promyelocytic leukemia cells and prostate cancer cells, regardless of p53 status [4,5]; however, β-Lap-induced apoptosis was also associated with the activation of p53-dependent apoptotic signaling in human prostate epithelial cells through the phosphorylation of p53, the induction of Bax, and the activation of caspases [43].