TP53 and colorectal cancer: It has been shown that OxPt-induced anticancer activity was significantly higher in wild-type p53-containing colorectal cancer cells than in mutant p53 or null-type p53, whereas OxPt-R properties were higher in null-type p53-containing colorectal cancer cells than wild-type p53 [38,39], suggesting that OxPt-induced anticancer activity and OxPt-R properties may be controlled by p53 status.