In addition, p53 is known to be upregulated in the nucleus via co-treatment with β-Lap and paclitaxel, a diterpene taxane natural compound, in Y79 human retinoblastoma cells, leading to apoptosis through the downregulation of Akt phosphorylation; however, p53 protein levels were not significantly altered by β-Lap treatment or paclitaxel alone [7]. This evidence concerns the gene TP53 and retinoblastoma.