SOD2 and breast carcinoma: It is known that lysine 9-acetylated histone H3 is upregulated at the MDR1 promoter in doxorubicin-resistant MCF-7 human breast cancer cells [44]; additionally, lysine 68-acetylated manganese superoxide dismutase (MnSOD) is associated with cisplatin and doxorubicin resistance due to aberrant mitochondria metabolism in MCF-7 cells [45].