The positive rates of CNN2 protein expression detected by immunohistochemistry were 37.5% (12/32) in non-metastasis HCC, 63.3% (19/30) in HCC with metastasis, 20.8% (5/24) in hepatitis, and 31.3% (10/32) in liver cirrhosis, respectively. This evidence concerns the gene CNN2 and hepatitis A virus infection.