With the onset of hypoglycemia, multiple counterregulatory responses act to reverse the hypoglycemic state, including a reduction in pancreatic ß-cell insulin release and increased pancreatic α-cell glucagon release through ATP-sensitive potassium (KATP) channel and glucokinase expression; a sympathoadrenal response where the hypoglycemic activation of the adrenal medulla induces epinephrine and norepinephrine secretion; and a delayed cortisol and growth hormone response [5,6]. Here, INS is linked to Hypoglycemia.