INS and type 1 diabetes mellitus: Alwafi et al. performed a systematic review encompassing 2,462,810 individuals and spanning all continents and showed that the prevalence of hypoglycemia among diabetics ranged from 0.074% to 73.0%, with the highest incidence and prevalence observed in T1D patients and those treated with insulin (prevalence range of 2.2% to 73.0%); additionally, the pooled prevalence among European and North American self-reported, cross-sectional studies included in this meta-analysis were 35.0% (95% CI, 32.0–38.0, I2 = 59%) and 11.0% (95% CI, 11.0–13.0, I2 = 38%), respectively [54].