MTHFR and non-small cell lung carcinoma: Concerning some of the genes analyzed in our study, MTHFR rs1801133 genotype AA has been associated with an increased likelihood of response to chemotherapy when treated with Pt-compounds, as well as UGT1A1 rs4148323 genotype AA which has been associated with a decreased response to cisplatin treatment in a cohort of East Asian patients with advanced NSCLC [22,30].