MAPK1 and retinal degeneration: Our study has three clear outcomes: (1) it identified potential retinal PKG substrates that could be involved in retinal degeneration, (2) it gave information on the kinase and pathway networks in operation during the degenerative events, and (3) it showed a correlation between the cGMP-PKG system and the RAS/RAF/MAPK/ERK pathway in this situation.