Among MMPs involved in glioblastoma progression, the ADAMs family stands out; it has been consistently shown that glioblastoma overexpresses mainly two members of the ADAMs family, ADAM 10 and ADAM 17 [24,25], suggesting a strong association between these two glycoproteins and glioblastoma progression [42,43] Based on the above evidence, we hypothesized to observe a decrease in ADAM 10 and ADAM 17 gene expression after exposure to the mTOR inhibitors. Here, MTOR is linked to glioblastoma.