IDH2 and glioma: Specifically, in the case of MBD1, we found that the splicing index of exon 10 was increased in the IDH-mutant glioma (mean PSI: 0.31) compared to IDH-WT (mean PSI: 0.13), indicating the higher expression of an MBD1 isoform containing this exon in the IDH-mutant glioma.