INSR and myotonic dystrophy type 1: The primary activity of boldine, observed as increased luciferase levels due to the modulation of the INSR minigene from DM1 to the no-DM1 condition in the presence of CTG repeats, was validated from the quantification of independent spliceosensor flies’ (8 points test), and without detecting unspecific off-targeting effects (Figure S1).