Following numerous preclinical investigations in cell cultures and murine tumor models of different tumor sites conducted to elucidate the effects of LPAR signaling in cancer progression, broadly speaking, LPAR1 and LPAR4 are associated with cell motility and invasion, LPAR2 is associated with cell survival against cancer therapy, LPAR3 and LPAR6 are associated with tumor proliferation and antitumor immunity via the regulation of dendritic cell migration, and LPAR5 is associated with immune cell evasion [26]. The gene discussed is LPAR5; the disease is cancer.