Spontaneous autoimmune mouse models, for example, the NZB strain, may develop autoimmune hemolytic anemia (AIHA) at various frequencies from the age of six months [7], while the first generation (F1) after crossing with the NZW strain (BW/F1) tend to develop an SLE-like condition between the ages of six and nine months, accompanied with a decreased level of IgM and an increase in anti-DNA IgG [8,10]. Here, CD40LG is linked to autoimmune hemolytic anemia.