Our results suggest for the first time that, in an MCD model of NASH, HuR levels are downregulated, and that the HuR targets MnSOD and HO-1 are downregulated as well, thus suggesting that a defective HuR-mediated modulation of antioxidant enzymes may contribute to the progression from simple steatosis to NASH. This evidence concerns the gene SOD2 and metabolic dysfunction-associated steatohepatitis.