The main aim of the present research was to investigate whether MCD diet-induced oxidative stress was associated with changes in the expression of HuR and of two of its targets, namely, MnSOD and HO-1, involved in antioxidant defense mechanisms; consequently, the MCD diet model was used since methionine-choline deficiency is known to induce a dramatic increase in oxidative stress [41]. This evidence concerns the gene SOD2 and hyperinsulinemic hypoglycemia, familial, 4.