The pivotal involvement of P2X7R in this process has been proven by recent findings showing that the administration of the orally applicable and CNS-penetrant P2X7R selective antagonist GSK1482160, which inhibits EV secretion from microglia, blocks tau propagation and rescues memory impairment in the P301S mouse model of tauopathy [77]. The gene discussed is MAPT; the disease is tauopathy.