CD4 and Leigh syndrome: This strong CXCL9/10/11 inflammatory signature influence supports our collective group’s prior work in LS (morphea) (Torok and Jacobe), including identification of CXCR3 ligand predominate expression in microarray skin [66], RNA bulk seq skin [67,68], and IHC skin [47,48], with close approximation of macrophages expressing CXCL9/10 and T cells (CD3/CD4) both adjacent to fibroblasts [47,48], and in peripheral blood via circulating cytokine [48,69,70] and flow cytometry [47] findings in LS subjects.