On the other hand, so-called hyperphosphorylation at certain epitopes (e.g., Thr181, Thr231, Ser202, Ser205, Ser214, Ser396, Ser404, Ser409, and Ser422) considerably changes the binding potential and stabilizing capacity properties of the tau protein, increasing the tendency for subsequent oligomerization and aggregation of tau into helical filaments and neurofibrillary tangles, which are characteristic of a group of neurodegenerative diseases called taupathies, including AD [13]. Here, MAPT is linked to Alzheimer disease.