In consistency with the suppression of pro-inflammatory cytokines (TNF-α, IFN-γ, and IL-6), it can be suggested that pretreatment with TBBt effectively relieves AKI, and its protective effects may be associated with the regulation of the MAPK-NF-κB-cytokines signaling pathway. The gene discussed is NFKB1; the disease is acute kidney injury.